ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children

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ApoE polymorphisms and diarrheal outcomes in Brazilian shanty town children.

A series of studies have shown that the heavy burdens of diarrheal diseases in the first 2 formative years of life in children living in urban shanty towns have negative effects on physical and cognitive development lasting into later childhood. We have shown that APOE4 is relatively common in shanty town children living in Brazil (13.4%) and suggest that APOE4 has a protective role in cognitiv...

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Faecal contamination of drinking water in a Brazilian shanty town: importance of household storage and new human faecal marker testing.

Worldwide, contaminated drinking water poses a major health threat, particularly to child development. Diarrhoea represents a large part of the water-related disease burden and enteric infections have been linked to nutritional and growth shortfalls as well as long-term physical and cognitive impairment in children. Previous studies detailed the frequency of infection and the consequences for c...

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Alzheimer disease (AD) is the most frequent cause of dementia in Western countries. Putative genetic risk factors for AD are polymorphisms in the apolipoprotein E (APOE) gene and in the low-density lipoprotein receptor-related protein (LRP) gene. Our objective was to investigate the role of the APOE coding region polymorphisms epsilon 2, epsilon 3, and epsilon 4 and APOE promoter variants A/T a...

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ژورنال

عنوان ژورنال: Brazilian Journal of Medical and Biological Research

سال: 2010

ISSN: 0100-879X

DOI: 10.1590/s0100-879x2010007500003